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AI Predicts Every NFL Week 10 Winner

2025-11-07Ryan Murphy Managing Editor6 minutes read
NFL
AI Predictions
Sports Betting

![Tampa Bay Buccaneers quarterback Baker Mayfield warming up before a game.](Photo By - Imagn Images. Tampa Bay Buccaneers quarterback Baker Mayfield (6) practices before the game against the Detroit Lions.)

As NFL Week 10 approaches with the intensity of a fourth-quarter blitz, we're leveraging cutting-edge technology for our game predictions. We provided ChatGPT with the latest NFL betting odds from FanDuel and tasked the advanced AI with selecting the straight-up moneyline winner for every game.

The AI model analyzed a variety of key inputs, including recent team performance, travel schedules, rest advantages, historical matchup data, and situational factors to make its selections. Whether you choose to follow the AI's logic or bet against it, the picks are locked in.

It's time to get your betting apps ready and settle in for a weekend of football. Let's see if we can ride the algorithm to a profitable week!

ChatGPT's NFL Week 10 Moneyline Picks

Here is a quick look at every winner predicted by the AI for the Week 10 slate:

  • Raiders vs Broncos: Broncos Broncos (-500)
  • Falcons vs Colts: Colts Colts (-270)
  • Ravens vs Vikings: Ravens Ravens (-220)
  • Patriots vs Buccaneers: Buccaneers Buccaneers (-142)
  • Jaguars vs Texans: Texans Texans (-104)
  • Browns vs Jets: Jets Jets (+108)
  • Saints vs Panthers: Panthers Panthers (-250)
  • Giants vs Bears: Bears Bears (-190)
  • Bills vs Dolphins: Bills Bills (-510)
  • Cardinals vs Seahawks: Seahawks Seahawks (-310)
  • Rams vs 49ers: Rams Rams (-205)
  • Lions vs Commanders: Lions Lions (-500)
  • Steelers vs Chargers: Chargers Chargers (-154)
  • Eagles vs Packers: Eagles Eagles (+118)

Lines are courtesy of FanDuel Sportsbook.

Game by Game AI Analysis

Raiders vs Broncos: Broncos (-500)

The Broncos' defense is in top form, and playing at high altitude on a short week gives them a significant edge against a traveling opponent. As the primetime home favorite, Denver's strategy for a win involves limiting mistakes early and controlling field position. For more details, see our full Raiders vs. Broncos breakdown.

Falcons vs Colts: Colts (-270)

For this game in Berlin, Indianapolis is the favorite due to their superior offensive balance, which will be crucial in a game centered on possession. While Atlanta will aim for a ball-control strategy, the Colts have been more effective in the red zone recently, leading us to back them on the moneyline.

Ravens vs Vikings: Ravens (-220)

Market sentiment has shifted towards Baltimore, now favored on the road. The deciding factor is the Ravens' potent pass rush against a sometimes-shaky Vikings offensive line. Furthermore, Baltimore's efficiency on crucial late downs makes them a reliable pick away from home.

Patriots vs Buccaneers: Buccaneers (-142)

Playing at home, Tampa Bay has a better turnover differential and is the favorite. In what projects to be a tight contest, the Buccaneers' ability to manage field position and minimize errors should secure the victory. We're taking the straightforward home favorite.

Jaguars vs Texans: Texans (-104)

Houston's offense has consistently performed well, making them the home favorite. In a game likely to be won or lost in the red zone, the Texans' more stable passing game gives them the edge in their home stadium.

Browns vs Jets: Jets (+108)

This matchup projects as a defensive struggle where variance is high. However, the Jets' advantage in special teams gives them a slight edge for a moneyline victory. Expect a grind-it-out game where field position and home-field advantage play a major role.

Saints vs Panthers: Panthers (-250)

Carolina is a deserving favorite. Their game plan focuses on a low-variance outcome at home: a strong running game, efficient offense, and a defense that prevents big plays. Against a Saints team struggling to finish drives, the Panthers can control the game's pace and secure the win.

Giants vs Bears: Bears (-190)

With Chicago favored at home, this game will be won in the trenches. The Bears' effective run game and quarterback mobility are key advantages. In a straight-up pick, the combination of home-field advantage and better late-down performance points to a Chicago victory.

Bills vs Dolphins: Bills (-510)

Buffalo is a heavy favorite, and historical matchups have consistently gone their way. If the Bills can avoid turnovers, their consistent down-to-down performance should be enough to win. While Miami relies on explosive plays, the moneyline pick is firmly with Buffalo.

Cardinals vs Seahawks: Seahawks (-310)

As the strong home favorite, Seattle is expected to dominate. The Seahawks' pass rush, amplified by the home crowd, will likely disrupt Arizona's offense. In this context, Seattle has a much higher floor for performance and is the clear choice.

Rams vs 49ers: Rams (-205)

The Rams are rightly favored, as their offense has been firing on all cylinders. Matthew Stafford is executing the play-action pass effectively, and the team has been excellent at converting drives into touchdowns. With solid protection and a knack for starting strong, the Rams are positioned to control this game.

Lions vs Commanders: Lions (-500)

Detroit continues to be a market favorite. Their balanced offense and red-zone efficiency are tough to stop, especially with key players out for Washington. We're backing the heavy favorite, as the Commanders' path to victory is incredibly narrow.

Steelers vs Chargers: Chargers (-154)

This primetime game in Los Angeles favors the Chargers. The matchup highlights their potential for explosive passing plays and a disruptive pass rush. Unless Pittsburgh can generate multiple takeaways, the Chargers are the more likely team to win outright.

Eagles vs Packers: Eagles (+118)

The Eagles' strength on both the offensive and defensive lines gives them an advantage, especially in tough conditions at Lambeau Field. Their ability to dominate in short-yardage situations, sustain drives, and pressure the opposing quarterback makes them a strong pick, even as the underdog. If Philadelphia can avoid costly mistakes, their power in the trenches should lead them to victory.


So far this season, ChatGPT has a record of 90-44 for a profit of +37.82 units.

Disclaimer: Odds are correct at the time of publishing and are subject to change. Not intended for use in MA. Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

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