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ChatGPT vs UpToDate Who Explains Appendicitis Better

2025-11-01Why publish in Cureus? Click below to find out.2 minutes read
AI
Healthcare
Readability

As artificial intelligence becomes a go-to source for information, many people are turning to tools like ChatGPT for health advice. But is the information easy to understand, especially when compared to resources written for medical professionals? A recent study delved into this question by comparing medical content on acute appendicitis from ChatGPT and UpToDate, a trusted clinical resource for doctors.

Pitting AI Against the Medical Standard

Researchers conducted a study to see how easy it was to read information about acute appendicitis, a common surgical emergency. They generated six different responses on the topic from the AI model ChatGPT-4o and compared them to six articles from UpToDate. The goal was to objectively measure which source produced content that was more accessible to the average person.

How Readability Was Measured

The team used a tool called WebFX to analyze the text from both sources. They looked at several key metrics, including word count, sentence length, and the number of difficult words. They also used standard readability formulas like the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL) to assess the complexity of the content. Statistical tests were then used to determine if the differences between ChatGPT and UpToDate were significant.

A Tale of Two Outputs Brevity vs Clarity

The results revealed a fascinating trade-off. UpToDate, designed for clinicians, produced longer articles with more words per sentence. In contrast, ChatGPT's responses were much more concise and to the point.

However, conciseness didn't automatically mean simplicity. While ChatGPT used fewer difficult words in total, these complex terms made up a significantly higher percentage of its overall text compared to UpToDate. This suggests that while the AI's answers are shorter, they may be packed with more technical jargon. Interestingly, when looking at overall readability scores like grade level, there was no statistically significant difference between the two sources.

The Verdict Whats Better for Patients

The study concluded that while ChatGPT excels at producing brief, summarized content, its higher proportion of difficult words could be a barrier to comprehension for patients. This highlights a critical challenge for AI in healthcare: the need to strike the right balance between being concise and being clear. For AI to be a truly effective tool for patient education, it must deliver information that is not only brief but also simple enough for a non-medical audience to understand.

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