AI Predicts Every NFL Week 3 Winner
Photo By - Imagn Images. Kansas City Chiefs quarterback Patrick Mahomes (15) passes the ball against the Philadelphia Eagles.
Week 3 of the NFL season brings the first real tests of staying power. Fast starts meet stiffer competition, struggling teams fight to reset, and every matchup begins to shape this season’s direction. It’s the weekend when early storylines start turning into lasting realities.
Instead of relying on traditional analysts, we've turned to artificial intelligence for insights. Using the Week 3 moneyline odds from FanDuel, we prompted ChatGPT to select the straight-up winners for every game on the schedule.
Here’s how the AI sees Week 3 shaking out with its NFL predictions.
ChatGPT has gone 28-4 so far this season for +23.6 units.
ChatGPT's NFL Week 3 Moneyline Picks
| Matchup | Pick |
|---|---|
 Dolphins vs  Bills | -850 |
 Colts vs  Titans | -205 |
 Steelers vs  Patriots | -130 |
 Jets vs  Buccaneers | -320 |
 Raiders vs  Commanders | -186 |
 Rams vs  Eagles | -190 |
 Falcons vs  Panthers | -250 |
 Bengals vs  Vikings | -144 |
 Texans vs  Jaguars | +120 |
 Packers vs  Browns | -430 |
 Broncos vs  Chargers | -154 |
 Saints vs  Seahawks | -390 |
 Cardinals vs  49ers | -120 |
 Cowboys vs  Bears | -108 |
 Chiefs vs  Giants | -270 |
 Lions vs  Ravens | -250 |
Lines are courtesy of FanDuel and are correct at the time of publishing but are subject to change.
AI Game-by-Game Analysis
Dolphins vs Bills: Pick Bills (-850)
Buffalo is 2-0 and much more in rhythm than the Dolphins, who have looked shaky on both offense and defense. Josh Allen and company should dominate, especially at home. While Miami has shown flashes, a lack of consistency and defensive weaknesses will likely cost them here.
Colts vs Titans: Pick Colts (-205)
Indianapolis has demonstrated more balance, particularly through the air with Daniel Jones, and should be able to control the game's tempo. Tennessee has fallen behind early in games and has defensive vulnerabilities. On the road, the Colts are positioned to find just enough to win straight-up.
Steelers vs Patriots: Pick Steelers (-130)
Although New England has had its moments, Pittsburgh appears more battle-tested in close games and is better positioned to capitalize on miscues. The line is close, making this a slightly riskier pick, but the Steelers seem more likely to pull this one out.
Jets vs Buccaneers: Pick Buccaneers (-320)
The Jets are dealing with quarterback disruption, whereas the Bucs have managed to win in tight spots in earlier games. Playing at home, Tampa Bay should be able to exploit New York’s weakened offense. Though the payout isn’t huge, the Buccaneers look like the safer bet.
Raiders vs Commanders: Pick Commanders (-186)
While there are some question marks for Washington, such as quarterback health, they have enough home strength and a favorable matchup to get the edge. Las Vegas hasn’t shown consistency so far. If the Commanders can avoid turnovers, they should secure the win.
Rams vs Eagles: Pick Eagles (-190)
The Eagles are 2-0 after a win in their Super Bowl rematch. They’ve been efficient and resilient. The Rams have shown potential, but concerns about their offensive line and consistency could derail them in Philadelphia. The Eagles, especially at home, are the safer pick.
Falcons vs Panthers: Pick Falcons (-250)
Atlanta had a strong showing in Week 2, especially on defense, and they are favored for a reason. Carolina is still trying to find consistency, particularly on offense. The line suggests confidence in the Falcons, and the AI agrees: Atlanta should win outright.
Bengals vs Vikings: Pick Vikings (-144)
With Joe Burrow out, the Bengals are a different team. Minnesota has its own issues, but as favorites at home and with fewer questions, they have a better chance to deliver. The AI leans towards the Vikings.
Texans vs Jaguars: Pick Texans (+120)
Houston appears to have an easier profile this week. The Jaguars have had their moments but have also shown vulnerability, especially on defense. If the Texans can limit turnovers and generate consistent offense, they should take this game.
Packers vs Browns: Pick Packers (-430)
Green Bay has started the season well, while the Browns are 0-2 with serious offensive struggles. The gap in team strength, especially at QB and supporting roles, heavily favors the Packers. Even on the road, Green Bay is much more likely to win.
Broncos vs Chargers: Pick Chargers (-154)
The Chargers are at home, where they are a slight favorite, and they appear more consistent to this point. The Broncos have shown flashes but not enough to be trusted for an outright win.
Saints vs Seahawks: Pick Seahawks (-390)
Seattle has more stability and should dominate this matchup. The Saints are still trying to find a reliable offensive identity, especially on the road. Seattle is a big favorite for a reason.
Cardinals vs 49ers: Pick 49ers (-120)
The 49ers have been impressive even without some key players, and their defense remains elite. The Cardinals have put up competitive numbers, but the Niners’ home advantage and cohesion give them the edge.
Cowboys vs Bears: Pick Cowboys (-108)
This is one of the tighter matchups. The Bears are favored at home, but their defense gave up a lot in earlier games and their offense hasn’t been totally steady. The Cowboys have explosive potential and may outscore them. The AI backs Dallas in this close one.
Chiefs vs Giants: Pick Chiefs (-270)
Both teams started 0-2, but Kansas City has shown more individual weaponry and offensive upside. The Giants have put up yards, but their defense and discipline are questionable. On the road in primetime, the Chiefs are expected to make key adjustments and get the win.
Lions vs Ravens: Pick Ravens (-250)
Baltimore at home is tough, especially under the lights. Detroit had a great offensive showing in Week 2, but consistency is still a question. The Ravens have shown more balance, and this is a spot where home-field advantage and coaching matter. The AI picks the Ravens to take it.
