AI Predicts Every NFL Week 4 Game Winner

As the first month of NFL action concludes, a full slate of exciting games is on the horizon, from Thursday night matchups to a massive Monday doubleheader. Instead of relying on traditional pundits, we've turned to artificial intelligence for a fresh perspective on this week's games.
We provided ChatGPT with the Week 4 moneyline odds from FanDuel and tasked it with picking the straight-up winner for every single game on the schedule. Here's a look at how the AI sees Week 4 playing out, followed by a breakdown of its reasoning for each pick.
AI's Top Moneyline Picks for NFL Week 4
Matchup | Pick (Moneyline) |
---|---|
Seahawks vs Cardinals | Seahawks (-116) |
Vikings vs Steelers | Vikings (-146) |
Saints vs Bills | Bills (-1800) |
Titans vs Texans | Texans (-335) |
Browns vs Lions | Lions (-500) |
Commanders vs Falcons | Commanders (-116) |
Eagles vs Buccaneers | Eagles (-194) |
Panthers vs Patriots | Patriots (-240) |
Chargers vs Giants | Chargers (-290) |
Jaguars vs 49ers | 49ers (-168) |
Colts vs Rams | Rams (-180) |
Bears vs Raiders | Raiders (-110) |
Ravens vs Chiefs | Ravens (-146) |
Packers vs Cowboys | Cowboys (+265) |
Jets vs Dolphins | Dolphins (-154) |
Bengals vs Broncos | Broncos (-355) |
Lines are courtesy of FanDuel and are subject to change.
Game-by-Game AI Analysis
Here’s the reasoning behind each of ChatGPT's predictions for the week.
Seahawks vs Cardinals
AI Pick: Seahawks (-116)
Seattle's defense has proven to be the more consistent unit so far this season. In a divisional game between two 2-1 teams, the AI gives the edge to the slight road favorite, believing their pass rush will be the deciding factor on critical downs.
Vikings vs Steelers
AI Pick: Vikings (-146)
While neutral-site games can be unpredictable, Minnesota's offense has shown a higher potential early in the season. With travel being a non-factor, the AI leans toward the Vikings' ability to create more explosive plays.
Saints vs Bills
AI Pick: Bills (-1800)
Buffalo has been a powerhouse on both offense and defense throughout September, and the heavy odds reflect that dominance. While an upset is always possible, the Bills' superior quarterback play and overall depth make them the clear favorite at home.
Titans vs Texans
AI Pick: Texans (-335)
Houston’s defense has been clutch in key moments, and their balanced offense is well-equipped to capitalize if Tennessee falls behind. The AI sees the Texans' matchup advantages as justification for the significant moneyline.
Browns vs Lions
AI Pick: Lions (-500)
Detroit’s formidable defensive front is expected to pressure a volatile Cleveland offense. Playing at Ford Field, the Lions' balanced approach gives them a high floor and a strong advantage.
Commanders vs Falcons
AI Pick: Commanders (-116)
In what is essentially a toss-up, the AI believes Washington's defensive front can control the game against a Falcons offense that is still finding its groove. The slight advantage goes to the road team's ability to win at the line of scrimmage.
Eagles vs Buccaneers
AI Pick: Eagles (-194)
Although Tampa Bay has played Philadelphia tough in recent matchups, the Eagles' strength in the trenches and superior red-zone strategy tip the scales in their favor. The AI considers the price fair for the more talented roster.
Panthers vs Patriots
AI Pick: Patriots (-240)
New England’s defense has performed well on the road, and their effective ground game can control the clock. The AI predicts that if Carolina falls behind, their narrow margin for error will be exposed.
Chargers vs Giants
AI Pick: Chargers (-290)
The consistency of the Los Angeles passing attack gives them a significant advantage. If the Chargers can avoid turnovers, the matchup favors a comfortable win on the road.
Jaguars vs 49ers
AI Pick: 49ers (-168)
San Francisco's defense is designed to shut down big plays, while their run game can effectively drain the clock with a lead. While Jacksonville poses a threat, the 49ers are the higher-probability victor at home.
Colts vs Rams
AI Pick: Rams (-180)
The Rams' efficient passing game and creative red-zone plays give them a clear edge at home. Despite the Colts' recent tenacity, the AI favors L.A.'s superior skill players and pass protection.
Bears vs Raiders
AI Pick: Raiders (-110)
With both teams showing inconsistency, the AI leans toward the home team in this near pick'em matchup. If Las Vegas can protect the football and convert in the red zone, it should be enough to secure a victory.
Ravens vs Chiefs
AI Pick: Ravens (-146)
Playing at Arrowhead is always a challenge, but Baltimore’s powerful run game and defensive speed are built for the road. The AI sides with the Ravens to control the game's tempo and win the field position battle.
Packers vs Cowboys
AI Pick: Cowboys (+265)
The Dallas defense playing at home is expected to dictate the terms against a Green Bay offensive line that has been inconsistent. The AI sees the primetime matchup, especially on third downs, favoring the Cowboys.
Jets vs Dolphins
AI Pick: Dolphins (-154)
Miami's overall team speed and well-designed offense provide multiple ways to win at home. While the Jets' defense could make it a tough game, the Dolphins' big-play capability makes them worthy favorites.
Bengals vs Broncos
AI Pick: Broncos (-355)
The combination of Denver's stout defense and home-field altitude advantage presents a tough challenge for a Bengals offense that is still working to find consistency. The AI believes the Broncos' run game can seal the victory if they get a lead.
So far this season, ChatGPT's picks have a record of 39-9 for +26.4 units.