Back to all posts

AI Predicts Every NFL Week 4 Game Winner

2025-09-26Ryan Murphy Managing Editor5 minutes read
NFL
Sports Betting
Artificial Intelligence

![Philadelphia Eagles quarterback Jalen Hurts rushes the ball against the Los Angeles Rams.](Photo By - Imagn Images.)

As the first month of NFL action concludes, a full slate of exciting games is on the horizon, from Thursday night matchups to a massive Monday doubleheader. Instead of relying on traditional pundits, we've turned to artificial intelligence for a fresh perspective on this week's games.

We provided ChatGPT with the Week 4 moneyline odds from FanDuel and tasked it with picking the straight-up winner for every single game on the schedule. Here's a look at how the AI sees Week 4 playing out, followed by a breakdown of its reasoning for each pick.

AI's Top Moneyline Picks for NFL Week 4

MatchupPick (Moneyline)
Seahawks vs CardinalsSeahawks (-116)
Vikings vs SteelersVikings (-146)
Saints vs BillsBills (-1800)
Titans vs TexansTexans (-335)
Browns vs LionsLions (-500)
Commanders vs FalconsCommanders (-116)
Eagles vs BuccaneersEagles (-194)
Panthers vs PatriotsPatriots (-240)
Chargers vs GiantsChargers (-290)
Jaguars vs 49ers49ers (-168)
Colts vs RamsRams (-180)
Bears vs RaidersRaiders (-110)
Ravens vs ChiefsRavens (-146)
Packers vs CowboysCowboys (+265)
Jets vs DolphinsDolphins (-154)
Bengals vs BroncosBroncos (-355)

Lines are courtesy of FanDuel and are subject to change.

Game-by-Game AI Analysis

Here’s the reasoning behind each of ChatGPT's predictions for the week.

Seahawks vs Cardinals

AI Pick: Seahawks (-116)

Seattle's defense has proven to be the more consistent unit so far this season. In a divisional game between two 2-1 teams, the AI gives the edge to the slight road favorite, believing their pass rush will be the deciding factor on critical downs.

Vikings vs Steelers

AI Pick: Vikings (-146)

While neutral-site games can be unpredictable, Minnesota's offense has shown a higher potential early in the season. With travel being a non-factor, the AI leans toward the Vikings' ability to create more explosive plays.

Saints vs Bills

AI Pick: Bills (-1800)

Buffalo has been a powerhouse on both offense and defense throughout September, and the heavy odds reflect that dominance. While an upset is always possible, the Bills' superior quarterback play and overall depth make them the clear favorite at home.

Titans vs Texans

AI Pick: Texans (-335)

Houston’s defense has been clutch in key moments, and their balanced offense is well-equipped to capitalize if Tennessee falls behind. The AI sees the Texans' matchup advantages as justification for the significant moneyline.

Browns vs Lions

AI Pick: Lions (-500)

Detroit’s formidable defensive front is expected to pressure a volatile Cleveland offense. Playing at Ford Field, the Lions' balanced approach gives them a high floor and a strong advantage.

Commanders vs Falcons

AI Pick: Commanders (-116)

In what is essentially a toss-up, the AI believes Washington's defensive front can control the game against a Falcons offense that is still finding its groove. The slight advantage goes to the road team's ability to win at the line of scrimmage.

Eagles vs Buccaneers

AI Pick: Eagles (-194)

Although Tampa Bay has played Philadelphia tough in recent matchups, the Eagles' strength in the trenches and superior red-zone strategy tip the scales in their favor. The AI considers the price fair for the more talented roster.

Panthers vs Patriots

AI Pick: Patriots (-240)

New England’s defense has performed well on the road, and their effective ground game can control the clock. The AI predicts that if Carolina falls behind, their narrow margin for error will be exposed.

Chargers vs Giants

AI Pick: Chargers (-290)

The consistency of the Los Angeles passing attack gives them a significant advantage. If the Chargers can avoid turnovers, the matchup favors a comfortable win on the road.

Jaguars vs 49ers

AI Pick: 49ers (-168)

San Francisco's defense is designed to shut down big plays, while their run game can effectively drain the clock with a lead. While Jacksonville poses a threat, the 49ers are the higher-probability victor at home.

Colts vs Rams

AI Pick: Rams (-180)

The Rams' efficient passing game and creative red-zone plays give them a clear edge at home. Despite the Colts' recent tenacity, the AI favors L.A.'s superior skill players and pass protection.

Bears vs Raiders

AI Pick: Raiders (-110)

With both teams showing inconsistency, the AI leans toward the home team in this near pick'em matchup. If Las Vegas can protect the football and convert in the red zone, it should be enough to secure a victory.

Ravens vs Chiefs

AI Pick: Ravens (-146)

Playing at Arrowhead is always a challenge, but Baltimore’s powerful run game and defensive speed are built for the road. The AI sides with the Ravens to control the game's tempo and win the field position battle.

Packers vs Cowboys

AI Pick: Cowboys (+265)

The Dallas defense playing at home is expected to dictate the terms against a Green Bay offensive line that has been inconsistent. The AI sees the primetime matchup, especially on third downs, favoring the Cowboys.

Jets vs Dolphins

AI Pick: Dolphins (-154)

Miami's overall team speed and well-designed offense provide multiple ways to win at home. While the Jets' defense could make it a tough game, the Dolphins' big-play capability makes them worthy favorites.

Bengals vs Broncos

AI Pick: Broncos (-355)

The combination of Denver's stout defense and home-field altitude advantage presents a tough challenge for a Bengals offense that is still working to find consistency. The AI believes the Broncos' run game can seal the victory if they get a lead.

So far this season, ChatGPT's picks have a record of 39-9 for +26.4 units.

Read Original Post
ImaginePro newsletter

Subscribe to our newsletter!

Subscribe to our newsletter to get the latest news and designs.